Study of Simultaneous Equation and Partial Simultaneous Equation Methods for the Spectrophotometric Estimation of Rosiglitazone Maleate and Glimepiride in Tablets

Abstract

Two new, simple, sensitive, accurate and reproducible   spectrophotometric methods were developed for the simultaneous   estimation of rosiglitazone maleate and glimepiride in   combine dosage form. The methods employed are simultaneous   equation method and partial simultaneous equation   method. Method I employed generation and solving simultaneous   equations using 248.5 and 228.5 nm as two analytical   wavelengths and method II employed 312 and 228.5 nm as   λ₃ and λ₂. Both drugs obeyed Beer's law in the concentration   ranges of 2 to 16 μg/mL. Statistical analysis and recovery   studies validated the method. The method is found to be rapid,   precise and accurate and can easily be employed in the laboratory   for routine estimation of drugs.