Chemoinhibition of Mineralization of Urinary Stone Forming Minerals by Some Inorganic and Organic Salts of Aluminium in Aqueous and Urinary Milieu

Abstract

Chemoinhibition of mineralization of urinary stone forming minerals viz., calcium oxalate and calcium phosphate by some inorganic and organic salts of aluminium viz., aluminium chloride, aluminium acetate and aluminium citrate, have been studied in aqueous as well as in urinary milieu. Inhibition efficiency has been studied in an experimental model. Crystals were isolated from the centrifugates of inhibited solutions in aqueous medium and their infrared spectra were studied. Results revealed that aluminium chloride and aluminium citrate show a uniformly good inhibition of calcium oxalate and calcium phosphate mineralization (35 to 53 % inhibition above blank for oxalate and 42 to 75 % inhibition above blank for phosphate) in aqueous as well as urinary media. Aluminium acetate showed a good inhibition only in aqueous media. Aluminium citrate was found to be a particularly potent inhibitor. Infrared spectra of the crystals, isolated from the centrifugates of inhibited solutions, evidenced a bridging mode of C=O of oxalate and a coordinated mode of phosphate. Thus soluble complexation seem to be the probable mechanism behind inhibition of oxalate and phosphate mineralization by aluminium salts.