Antidiabetic Activity of Glycoside Isolated from Gymnema sylvestre in Streptozotocin Induced Diabetic Rats

Abstract

A study was undertaken to evaluate the antidiabetic activity of alcoholic extract of leaf of Gymnema sylvestre in streptozotocin induced diabetic rats. Glycoside is isolated from G. sylvestre investigated hypoglycemic activity of normal and streptozotocin induced diabetic rats and compared with glibenclamide reference drug. Gymnema sylvestre (250 mg/ kg/body weight) decrease blood glucose levels significantly (p < 0.05) at 2 and 4 h after the glucose load in glucose tolerance test. The results suggested that the alcoholic extract of Gymnema sylvestre possess significant hypoglycemic activity in normal and streptozotocin induced diabetic rats.