Synthesis of N'-(Substituted benzylidene)-1-benzofuran-2-carbohydrazide and 5-(5- Substituted-1-benzofuran-2-yl)-1,3,4-oxadiazole-2-thiol as Potent Antioxidants

Abstract

The reactions of substituted benzofuran-2-carbohydrazide (1) with various aromatic substituted aldehydes and carbon disulphide yielded corresponding N'-(substituted benzylidene)- 1-benzofuran-2-carbohydrazide (2a-f) and with CS₂ yielded 5-(5-substituted-1-benzofuran-2-yl)-1,3,4-oxadiazole-2-thiols (3a-c), respectively. The synthesized compounds were characterized by IR, ¹H NMR and mass spectra. All the compounds were screened for their in vitro antioxidant activity using DPPH method and antimicrobial activity by cup-plate diffusion method. The compounds 2c, 3a and 3b shown potent radical scavenging activity and 2a, 2d, 3b and 3c have shown moderate antimicrobial activity.