UV Spectrophotometric Determination of Oxaprozin in Pure and Pharmaceutical Formulation

Abstract

A simple, sensitive, spectrophotometric method in UV region has been developed for the determination of oxaprozin in bulk and tablet dosage form. Solution of oxaprozin in 0.1 N NaOH shows maximum absorbance at 285 nm with apparent molar absorptivity of 1.3082 × 10₄ L/mol cm. Beer's law was obeyed in the concentration range of 2-20 μg/mL with 0.9992 as and the slope, intercept were 0.0118, 0.04377, respectively. Results of the analysis were validated statistically and by recovery studies (100.21 ± 0.8709). Result of percentage recovery and placebo interference shows that that the method was not affected by the presence of excipients which proves suitability of the developed method for the routine estimation of oxaprozin in bulk and solid dosage form.