Synthesis of Xanthine Derivatives by Ring Closure Reaction
Corresponding Author(s) : Pravin B. Shejul
pravin@genesenlabs.com
Asian Journal of Chemistry,
Vol. 20 No. 7 (2008): Vol 20 Issue 7
Abstract
Ring closure of the imidazole ring is a key step in the synthesis of xanthine and other purine derivatives. A microwaveassisted procedure involving triethyl orthoformate is presented. High yields are achieved even on a gram scale, while reaction times are considerably shortened compared to conventional heating conditions.
Keywords
Microwave-assisted synthesis
Xanthines
Purines
Imidazole ring closure
(1)
B. Shejul, P.; H. Kadam, N.; V. Vyavahare, A.; B. Kasawar, G.; Panpaliya, P. Synthesis of Xanthine Derivatives by Ring Closure Reaction. ajc 2010, 20, 5441-5446.
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