Synthesis of Xanthine Derivatives by Ring Closure Reaction
Corresponding Author(s) : Pravin B. Shejul
pravin@genesenlabs.com
Asian Journal of Chemistry,
Vol. 20 No. 7 (2008): Vol 20 Issue 7
Abstract
Ring closure of the imidazole ring is a key step in the synthesis of xanthine and other purine derivatives. A microwaveassisted procedure involving triethyl orthoformate is presented. High yields are achieved even on a gram scale, while reaction times are considerably shortened compared to conventional heating conditions.
Keywords
Microwave-assisted synthesis
Xanthines
Purines
Imidazole ring closure
B. Shejul, P., H. Kadam, N., V. Vyavahare, A., B. Kasawar, G., & Panpaliya, P. (2010). Synthesis of Xanthine Derivatives by Ring Closure Reaction. Asian Journal of Chemistry, 20(7), 5441–5446. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/12877
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