Synthesis and Antimicrobial Activity of N-Norfloxacin Mannich Bases of Isatin and Its Derivatives

Abstract

Schiff bases of isatin (and derivatives) with isoniazid and their N-norfloxacin Mannich bases were synthesized. Their chemical structures have been confirmed by IR, ¹H NMR and by elemental analyses. Antimicrobial evaluation was done against twenty six pathogenic bacteria and six pathogenic fungi. Most of the N-Mannich bases showed higher activity against most of the bacteria in comparison to norfloxacin. All the fungal strains were sensitive to the synthesized N-Mannich bases at the concentration of 50 μg/mL.