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Vol. 29 No. 11 (2017): Vol 29 Issue 11

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Evaluation Performance of Molecularly Imprinted Polymer Prepared by Two Different Polymerization Method for Atenolol Recognition in Human Plasma

https://doi.org/10.14233/ajchem.2017.20728
Aliya Nur Hasanah
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjdjaran, Jl Raya Bandung Sumedang KM 21.5, 45363, Jatinangor, Sumedang, Indonesia
Shendi Suryana
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjdjaran, Jl Raya Bandung Sumedang KM 21.5, 45363, Jatinangor, Sumedang, Indonesia; Pharmacy Department, Faculty of Mathematics and Natural Sciences, Universitas Garut, Jl. Jati No. 42B 44151, Tarogong, Garut, Indonesia
Mutakin
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjdjaran, Jl Raya Bandung Sumedang KM 21.5, 45363, Jatinangor, Sumedang, Indonesia
Driyanti Rahayu
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjdjaran, Jl Raya Bandung Sumedang KM 21.5, 45363, Jatinangor, Sumedang, Indonesia

Corresponding Author(s) : Aliya Nur Hasanah

aliya.n.hasanah@unpad.ac.id; aliya_nh@yahoo.com

Asian Journal of Chemistry, Vol. 29 No. 11 (2017): Vol 29 Issue 11

Abstract

Two molecularly imprinted polymers (MIPs) were prepared via bulk polymerizations and precipitation polymerization with methacrylic acid as functional monomer, atenolol as the template, ethylene glycol di-methacrylate as a crosslinker. Molecularly imprinted polymer prepared via precipitation polymerization gives the best character as sorbent by a higher number of binding site and higher association constant compared to bulk. Plasma sample which was spiked with atenolol gives recovery more than 96 % after pretreatment with selected polymer. Selectivity test showed that MIP made by precipitation polymerization could be used for selective recognition of atenolol from plasma samples spiked with other drugs. This developed molecularly imprinted polymer-solid phase extraction (MIP-SPE) could be further used as extraction method in antihypertension drug analysis from biological samples.

Keywords

Molecularly imprinted polymer Atenolol molecular recognition Solid phase extraction
Hasanah, A. N., Suryana, S., Mutakin, ., & Rahayu, D. (2017). Evaluation Performance of Molecularly Imprinted Polymer Prepared by Two Different Polymerization Method for Atenolol Recognition in Human Plasma. Asian Journal of Chemistry, 29(11), 2429–2433. https://doi.org/10.14233/ajchem.2017.20728
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