Synthesis and Antiinflammatory Activity of Some 2-(Substituted phenyl)-3-(4,5- diphenyl-1H-imidazol-2-yl)-1,3-thiazolidin-4-one Derivatives

Abstract

4,5-Diphenylimidazoline-2-amine (I) was treated with different aryl aldehydes in ethanol to yield the corresponding Schiff bases (IIa-e). The Schiff bases (IIa-e) on refluxing with thioglycolic acid in 1,4-dioxane yielded 2-(substituted phenyl)-3-(4,5-diphenyl-1H-imidazol-2-yl)-1,3-thiazolidin-4- one (IIIa-e). The compounds were characterized by elemental analysis, ¹H NMR, mass and IR spectral studies. All the title compounds were screened for antiinflammatory activity. Compounds IIIa, IIIb and IIId have exhibited good antiinflammatory activity.