Polymeric Membrane Electrode for Potentiometric Determination of Atenolol in Tablets and Biological Fluids

Abstract

A PVC membrane electrode of atenolol and phosphomolybdic acid association complex was constructed. The basic electrode's performance characteristics were evaluated. The prepared electrode exhibits a Nernstain response (30.8 ± 0.1 mV/decade) over the concentration range of atenolol 1 × 10^-2–1 × 10^-6 M of solutions of pH 3-8. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 10 × 10^-2–1 × 10^-6 M aqueous atenolol using this membrane electrode system showed an average recovery of 99.03 with mean standard deviation ± 0.7. The electrode gave a good stability, reproducibility and fast response. These characteristics of the electrode enable it to be used successfully for the determination of atenolol in pure form, pharmaceutical preparations and in biological fluids.