Ophthalmic Inserts of Piroxicam: Development andin vitroDrug Release Studies

Abstract

With the limit-ations of conventional ocular preparations the aim of the present study was to formulate once a day piroxicam releasing ocular inserts and to study the drug release of piroxicam in different release media. Piroxicam films were made with cross-linked and non-cross-linked gelatin matrix and hence the effect of cross linking on drug release was also studied. Drug release was studied separately in distilled water, simulated tear fluid and phosphate buffered saline (pH 7.4) at 37 °C. The release rates of piroxicam from cross-linked (1, 4 and 8 h) formulations were slower than the non cross-linked formulation in all the three release media. Increasing the crosslinking time decreased the release rates. The overall release rates were similar in simulated tear fluid and phosphate buffered saline (pH 7.4), while it was lower in distilled water.