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Conventional and Microwave Assisted Synthesis of Quinoxaline Carboxamide Derivatives
Corresponding Author(s) : M. Thirumala Chary
Asian Journal of Chemistry,
Vol. 29 No. 11 (2017): Vol 29 Issue 11
Abstract
The synthesis of carboxamide derivatives containing quinoxaline scaffold is described. They were prepared from 3-hydroxy quinoxaline-2-carbohydrazide in a series of steps using conventional as well as microwave assisted methods.
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- A. Carta, P. Sanna, L. Gherardini, D. Usai and S. Zanetti, IL Farmaco, 56, 933 (2001); https://doi.org/10.1016/S0014-827X(01)01161-2.
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- Y.A. Ammar, M.M.F. Ismail, M.S.A. El-Gaby and M.A. Zahran, Indian J. Chem., 41B, 1486 (2002).
- V.K. Tandon, D.B. Yadav, H.K. Maurya, A.K. Chaturvedi and P.K. Shukla, Bioorg. Med. Chem., 14, 6120 (2006); https://doi.org/10.1016/j.bmc.2006.04.029.
- H.M. Refaat, A.A. Moneer and O.M. Khalil, Arch. Pharm. Res., 27, 1093 (2004); https://doi.org/10.1007/BF02975110.
- U.J. Ries, H.W.M. Priepke, N.H. Hauel, S. Handschuh, G. Mihm, J.M. Stassen, W. Wienen and H. Nar, Bioorg. Med. Chem. Lett., 13, 2297 (2003); https://doi.org/10.1016/S0960-894X(03)00443-8.
- L.W. Deady, A.J. Kaye, G.J. Finlay, B.C. Baguley and W.A. Denny, J. Med. Chem., 40, 2040 (1997); https://doi.org/10.1021/jm970044r.
- P. Marqués-Gallego, M.A. Gamiz-Gonzalez, F.R. Fortea-Pérez, M. Lutz, A.L. Spek, A. Pevec, B. Kozlevcar and J. Reedijk, Dalton Trans., 39, 5152 (2010); https://doi.org/10.1039/C001158D.
- R. Mahesh, T. Devadoss, D.K. Pandey and S.K. Yadav, J. Enzyme Inhib. Med. Chem., 26, 610 (2011); https://doi.org/10.3109/14756366.2010.543419.
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References
A. Carta, P. Sanna, L. Gherardini, D. Usai and S. Zanetti, IL Farmaco, 56, 933 (2001); https://doi.org/10.1016/S0014-827X(01)01161-2.
J.J. Cai, J.P. Zou, X.Q. Pan and W. Zhang, Tetrahedron Lett., 49, 7386 (2008); https://doi.org/10.1016/j.tetlet.2008.10.058.
P. Sanna, A. Carta, M. Loriga, S. Zanetti and L. Sechi, IL Farmaco, 54, 1169 (1999).
Y.A. Ammar, M.M.F. Ismail, M.S.A. El-Gaby and M.A. Zahran, Indian J. Chem., 41B, 1486 (2002).
V.K. Tandon, D.B. Yadav, H.K. Maurya, A.K. Chaturvedi and P.K. Shukla, Bioorg. Med. Chem., 14, 6120 (2006); https://doi.org/10.1016/j.bmc.2006.04.029.
H.M. Refaat, A.A. Moneer and O.M. Khalil, Arch. Pharm. Res., 27, 1093 (2004); https://doi.org/10.1007/BF02975110.
U.J. Ries, H.W.M. Priepke, N.H. Hauel, S. Handschuh, G. Mihm, J.M. Stassen, W. Wienen and H. Nar, Bioorg. Med. Chem. Lett., 13, 2297 (2003); https://doi.org/10.1016/S0960-894X(03)00443-8.
L.W. Deady, A.J. Kaye, G.J. Finlay, B.C. Baguley and W.A. Denny, J. Med. Chem., 40, 2040 (1997); https://doi.org/10.1021/jm970044r.
P. Marqués-Gallego, M.A. Gamiz-Gonzalez, F.R. Fortea-Pérez, M. Lutz, A.L. Spek, A. Pevec, B. Kozlevcar and J. Reedijk, Dalton Trans., 39, 5152 (2010); https://doi.org/10.1039/C001158D.
R. Mahesh, T. Devadoss, D.K. Pandey and S.K. Yadav, J. Enzyme Inhib. Med. Chem., 26, 610 (2011); https://doi.org/10.3109/14756366.2010.543419.
D.S. Su and M.G. Bock, 2-Quinoxalinone Derivatives as Bradykinin Antagonists and Novel Compounds, US Patent 20050020591 (2005).