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Vol. 20 No. 5 (2008): Vol 20 Issue 5

Michael Addition to Nalidixic Acid and its Antitubercular Activity

P. RAMALINGAM
Department of Pharmaceutical and Medicinal Chemistry, Siddharth Institute of PharmacyNalanda Educational Campus, Kantepudi, Sattenapalli (M), Guntur-522 438, India
CH. BABURAO
Department of Pharmaceutical and Medicinal Chemistry, Siddharth Institute of PharmacyNalanda Educational Campus, Kantepudi, Sattenapalli (M), Guntur-522 438, India
S. GANAPATY
Department of Pharmaceutical and Medicinal Chemistry, Siddharth Institute of PharmacyNalanda Educational Campus, Kantepudi, Sattenapalli (M), Guntur-522 438, India

Corresponding Author(s) : P. RAMALINGAM

rammpharm@rediffmail.com

Asian Journal of Chemistry, Vol. 20 No. 5 (2008): Vol 20 Issue 5

Abstract

α,β-Unsaturated site of nalidixic acid was subjected to Michael addition that afforded 14 new derivatives. All the compounds were characterized by spectral data and evaluated for its antitubercular activity against Mycobacterium tuberculosis H37Rν by Alamar blue assay.

Keywords

Nalidexic acid Michael addition Antitubercular
(1)
RAMALINGAM, P.; BABURAO, C.; GANAPATY, S. Michael Addition to Nalidixic Acid and Its Antitubercular Activity. ajc 2010, 20, 4135-4137.
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