Synthesis, Spectroscopic Studies and Antimicrobial Activity of Phosphazenes Derivatives

Abstract

The monosubstituted, fullysubstituted trimericphosphazenes, poly(dichloro)phosphazenes and poly(diorgano)phosphazene with para-substituted anilino side groups have been synthesized. The p-substituents is fluorine groups. The poly(diorgano)phosphazene was prepared by two routes. A direct synthetic route to the poly(diorgano)phosphazene was prepared by polycondensation of mono and fullysubstituted monomer. Second route is the substitution of the chlorine atoms in poly(dichloro)- phosphazene by organic groups, giving a poly(diorgano)phosphazene. The monomers and polymers were analyzed by elemental analysis, IR, ¹H, ¹³C and ³¹P NMR spectra. The number average molecular weight, M_n, mass average molecular weight, M_w and polydispersity index values of compounds 3 and 4 were found to be 722 967 g mol^-1, 755 005 g mol^-1 and 1.044 g mol^-1 and 557 448 g mol^-1, 699 315 g mol^-1 and 1.25, respectively. TG data was shown to be stable of compound 4 against thermo-oxidative decomposition. The weight loss of compound 4 was found to be 50 % at 500 °C and 34 % at 800 °C, respectively. The antimicrobial activities of the monomers and polymer have been screened in vitro against the organisms Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae UC57, Micrococcus luteus La 2971, Proteus vulgaris ATCC 8427, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis CCM 2067, Bacillus cereus ATCC 7064, Listeria monocytogenes ATCC 15313, Candida albicans ATCC 10231, Kluyveromyces fragilis NRRL 2415, Rhodotorula rubra DSM 70403, Hanseniaspora guilliermondii DSM 3432 and Debaryomyces hansenii DSM 70238. It is observed that the polymer has pronouned effect on the microbial activities of the monomer. The polymer has higher antimicrobial effect than the monomer.