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Vol. 20 No. 4 (2008): Vol 20 Issue 4

Hypo and Antihyperglycaemic Effect of Citrullus colocinthis L. Seeds in Normal and Streptozotocin-Induced Diabetic Rats

H. BENMEHDI
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria Fax: (43)286530; E-mail: h_allali72@yahoo.fr
H. ALLALI
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria
B. TABTI
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria
N. DJABOU
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria
A. BENDIABDELLAH
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria
F. LAHFA
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria
R. DJAZIRI
Laboratory of Organic Chemistry, Naturals Products and Analysis (COSNA) Department of Chemistry, Faculty of Sciences, University of Aboubekr Belkaïd BP 119, 13000, Tlemcen, Algeria

Corresponding Author(s) : H. ALLALI

h_allali72@yahoo.fr

Asian Journal of Chemistry, Vol. 20 No. 4 (2008): Vol 20 Issue 4

Abstract

Citrullus colocinthis L. is used in Algerian folk medecine for the treatment of diabetes mellitus. Intra peritoneal administration of the aqueous extract of the seed (1.25 g/kg body weight) to streptozotocin-induced diabetic rats produced a significant reduction of blood sugar level in the long term, while the same extract produced no alteration of glycaemia in normal rats in the short term. The aqueous extract of this plant seems to have maximal adverse effect and high LD100 value.

Keywords

Hypoglycaemic Glucose Extracts Streptozotocin Citrullus colocinthis L.
BENMEHDI, H., ALLALI, H., TABTI, B., DJABOU, N., BENDIABDELLAH, A., LAHFA, F., & DJAZIRI, R. (2010). Hypo and Antihyperglycaemic Effect of Citrullus colocinthis L. Seeds in Normal and Streptozotocin-Induced Diabetic Rats. Asian Journal of Chemistry, 20(4), 2711–2718. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/12639
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