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Synthesis of New Heterocyclic Nitrogen System Bearing Thiazolopyrazole Moiety as New Biocidal Agents
Corresponding Author(s) : L.A. Taib
Asian Journal of Chemistry,
Vol. 29 No. 11 (2017): Vol 29 Issue 11
Abstract
Novel heteropolycyclic nitrogen systems as pyrazoles, phthalazines and 1,2,4-triazines bearing a thiazolopyrazole moiety (4-11) have been synthesized via heterocyclization of 2-hydrazino-thiazolo[5,4-d]pyrazole (3) with a,b-bifunctional compounds under different conditions. Structures of the new products established by their elemental analysis and spectral data. Some of these products exhibit moderate-good antibacterial activity towards E. coli and S. aureus in compare with streptomycin and tetracycline antibiotic.
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- R.M. Abdel-Rahman, Boll. Chim. Farm., 140, 401 (2001).
- S. Kamila, H. Ankati and E.R. Biehl, Tetrahedron Lett., 52, 4375 (2011); https://doi.org/10.1016/j.tetlet.2011.05.114.
- M.T. Zaki, R.M. Abdel-Rahman and A.Y. El-Sayed, Anal. Chim. Acta, 307, 127 (1995); https://doi.org/10.1016/0003-2670(95)00048-5.
- D.A. Bakhotmah and R.M. Abdel-Rahman, Org. Chem., 13, 62 (2016); https://doi.org/10.2174/1570193X13666160225000114.
- Z. El-Gendy, R.M. Abdel-Rahman and M.S. Abdel-Malik, Indian J. Chem., 28B, 479 (1989).
- R.M. Abdel-Rahman and H.A. Saad, Curr. Org. Synth., 13, 408 (2016); https://doi.org/10.2174/1570179412666150905001956.
- R.M. Abdel-Rahman, M.S.T. Makki, T.E. Ali and M.A. Ibrahim, J. Heterocycl. Chem., 52, 1595 (2015); https://doi.org/10.1002/jhet.2014.
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- R.M. Abdel-Rahman, M.S.T. Makki, T.E. Ali and M.A. Ibrahim, Curr. Org. Synth., 10, 136 (2013); https://doi.org/10.2174/1570179411310010006.
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- N. Cong, H. Nhan, L. Van Hung, T. Thang and P.-C. Kuo, Molecules, 19, 13577 (2014); https://doi.org/10.3390/molecules190913577.
- T. Tomasic, A. Kovac, M. Simcic, D. Blanot, S.G. Grdadolnik, S. Gobec, D. Kikelj and L. Peterlin Masic, Eur. J. Med. Chem., 46, 3964 (2011); https://doi.org/10.1016/j.ejmech.2011.05.070.
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References
R.M. Abdel-Rahman, Boll. Chim. Farm., 140, 401 (2001).
S. Kamila, H. Ankati and E.R. Biehl, Tetrahedron Lett., 52, 4375 (2011); https://doi.org/10.1016/j.tetlet.2011.05.114.
M.T. Zaki, R.M. Abdel-Rahman and A.Y. El-Sayed, Anal. Chim. Acta, 307, 127 (1995); https://doi.org/10.1016/0003-2670(95)00048-5.
D.A. Bakhotmah and R.M. Abdel-Rahman, Org. Chem., 13, 62 (2016); https://doi.org/10.2174/1570193X13666160225000114.
Z. El-Gendy, R.M. Abdel-Rahman and M.S. Abdel-Malik, Indian J. Chem., 28B, 479 (1989).
R.M. Abdel-Rahman and H.A. Saad, Curr. Org. Synth., 13, 408 (2016); https://doi.org/10.2174/1570179412666150905001956.
R.M. Abdel-Rahman, M.S.T. Makki, T.E. Ali and M.A. Ibrahim, J. Heterocycl. Chem., 52, 1595 (2015); https://doi.org/10.1002/jhet.2014.
M.S.I. Makki, R.M. Abdel-Rahman and K.A. Khan, J. Chem., Article ID 430573 (2014); https://doi.org/10.1155/2014/430573.
R.M. Abdel-Rahman, M.S.T. Makki, T.E. Ali and M.A. Ibrahim, Curr. Org. Synth., 10, 136 (2013); https://doi.org/10.2174/1570179411310010006.
R.M. Abdel-Rahman, M.S.T. Makki, T.E. Ali and M.A. Ibrahim, Eur. J. Chem., 1, 236 (2010); https://doi.org/10.5155/eurjchem.1.3.236-245.54.
N. Cong, H. Nhan, L. Van Hung, T. Thang and P.-C. Kuo, Molecules, 19, 13577 (2014); https://doi.org/10.3390/molecules190913577.
T. Tomasic, A. Kovac, M. Simcic, D. Blanot, S.G. Grdadolnik, S. Gobec, D. Kikelj and L. Peterlin Masic, Eur. J. Med. Chem., 46, 3964 (2011); https://doi.org/10.1016/j.ejmech.2011.05.070.
H. Park, P.N. Chien and S.E. Ryu, Bioorg. Med. Chem. Lett., 22, 6333 (2012); https://doi.org/10.1016/j.bmcl.2012.08.081.