Antibacterial and Antifungal Evaluation of Potent N-Hydroxy-2,6-diaryl-3,5-dimethylpiperidin-4-one Oximes

Abstract

N-hydroxy-2,6-diaryl-3,5-dimethylpiperidin-4-one oximes [3a-f] obtained by the reaction between the N-hydroxy-2,6-diaryl-3,5-dimethylpiperidin-4-ones [2a-f] and hydroxyl amine hydrochloride are screened against selected bacteria (Vibro cholerae, Salmonella typii, Shigella flexneri, Escherichia coli, Staphylococous aureus, Klebsiella pneummonia, β-Heamolytic streptococcus and Pseudomonas) and fungi (Aspergillus flavus, Mucor, Microsporum gypseum and Rhizopus). Disc diffusion method is employed to determine the in vitro antibiotic effect. The inhibitory effect of the compounds is very close and identical in magnitude and is comparable with that of the standard antibiotic used.