Synthesis and Antimicrobial Activity of 1-(Benzothiazol-2'-yl)-5-phenyl-tetrazole

Abstract

In the present study, a new series of 1-(benzothiazol-2'- yl)-5-phenyl-tetrazole were synthesized by the reaction of Schiff base (2-aminobenzothiazole and substituted benzaldehyde) with phosphorous pentachloride and sodium azide. The chemical structures of the synthesized compounds were confirmed by means of IR, ¹H NMR, mass spectral and elemental analysis. The synthesized compounds were screened for antibacterial (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa), antifungal (Aspergillus niger and Candida albicans). The synthesized compounds exhibited good antibacterial and significant antifungal activity at the dose of 250 μg/mL by Paper disc diffusion method.