A Novel Study on Bioactive 2-Substituted Amino-5-benzothiazol-2-oyl-4-phenylthiazoles

Abstract

Amino or substituted aminothiazoles exhibit bacterial, fungicidal, herbicidal and pesticidal properties. The (4+1) thiazole construction strategy adopted involves the synthesis of the [C-N-C-S] precursors, namely 1-aryl-3-(N-phenylbenzimidoyl) thiourea or 1-alkyl-3-(N-phenylbenzimidoyl)- thiourea and the preparation of the C5 synthone, the halo acetylhetaroyl derivative. The optimized reaction conditions developed have thus lead to the preparation of five 2-(N-arylamino)- 5-(benzothiazol-2-oyl)-4-phenylthiazoles and three 2-(N,N-dialkylamino)-5-(benzothiazol-2-oyl)-4-phenylthiazoles. The structure of these compounds were assigned on the basis of elemental analysis, FTIR, ¹H NMR and ¹³C NMR and screened for their antimicrobial activity.