Optimized Buccoadhesive Miconazole Tablet Using Simplex Centroid Experimental Design

Abstract

The purpose of present work was to prepare miconazole nitrate buccal adhesive preparations using simplex centroid experimental design to optimize polymer ratio, which will provide desired drug release and mucoadhesion to prepared tablets. Various polymers such as carbopol 934P, hydroxy propyl methylcellulose K4M and sodium carboxy methyl cellulose to prepare buccal adhesive tablet of miconazole nitrate. Tablet properties such as swelling index, mucoadhesive strength and in vitro drug release were evaluated. The drug release and bioadhesion was dependent on type and composition of the polymer used. The combination, which gave good result, was further optimized using a simplex centroid experiment design. The dissolution of miconazole from tablets was sustained for 6 h. Based on the results obtained, it can be said that prepared slow release buccoadhesive tablets of miconazole would markedly prolong the duration of the antifungal activity with more patient compliance.