A Facile Synthesis of 7-Hydroxy-4-methyl-8-heteryl-2H-2-chromenones
Corresponding Author(s) : P. PRATAP REDDY
prataprp@drreddys.com
Asian Journal of Chemistry,
Vol. 20 No. 2 (2008): Vol 20 Issue 2
Abstract
7-Hydroxy-4-methyl-8-(1H-3-pyrazolyl)-2H-2-chromenones and 7-hydroxy-8-(3-isoxazolyl-4-methyl-2H-2-chromenones were prepared by a two step synthetic sequence starting from 8-acetyl- 7-hydroxyl-4-methyl-2H-2-chromenones. Reaction of 8-acetyl chromenone derivatives with dimethylformamide-dimethylacetal (DMF-DMA) and subsequent condensation of the resulted enaminones with hydrazines and hydroxylamine hydrochloride furnished the desired products in high yields.
Keywords
8-Acetyl-7-hydroxy-4-methyl-2H-chromenones
Hydroxylamine hydrochloride
Hydrazine derivatives
Oxazoles
Pyrazoles
RAGHOTHAM, A., LAVANYA, T., & PRATAP REDDY, P. (2010). A Facile Synthesis of 7-Hydroxy-4-methyl-8-heteryl-2H-2-chromenones. Asian Journal of Chemistry, 20(2), 1285–1289. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/12539
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