Synthesis of Bis(indolyl)methanes in Presence of Anhydrous Copper(II) Sulfate

Abstract

This work reports the improved procedure for the preparation of bis(indolyl)methanes from the corresponding aldehydes and indole. Anhydrous copper(II) sulfate efficiently promotes the chemoselective synthesis of bis(indolyl)- methanes via electrophilic substitution reactions of indole with aldehydes. The reaction was carried out in refluxing dichloromethane or microwave-assisted solvent-free conditions. The adducts were produced in good to excellent yields.