Synthesis of Some Hydroxymethyl Derivatives of 4H-Pyran-4-ones via N–O Bond Cleavage

Abstract

A new method was developed for the synthesis of hydroxymethyl derivatives of 4H-pyran-4-ones from corresponding phthalimidoxymethyl derivatives by reduction of N–O bond with zinc powder and hydrochloric acid. These phthalimidoxymethyl derivatives of 4H-pyran-4-ones were synthesized by means of reactions of their bromomethyl derivatives and N-hydroxyphthalimide.