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Vol. 29 No. 10 (2017): Vol 29 Issue 10

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Synthesis, Characterization, Molecular Docking, Thermal Degradation Studies and Biological Screening of N-{[2-(Pyridin-4-ylcarbonyl)hydrazinyl]carbonothioyl}furan-2-carboxamide and its Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) Complexes

https://doi.org/10.14233/ajchem.2017.20676
T.C.M. Yuvaraj
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India
P. Parameshwara Naik
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India
G. Krishnamurthy
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India
T.V. Venkatesh
Department of Chemistry, Kuvempu University, Shankaraghatta-577 451, India
R. Mohammed Shafeeulla
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India
T. Manjuraj
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India
T.M. Venugopal
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India

Corresponding Author(s) : P. Parameshwara Naik

parashchem@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 10 (2017): Vol 29 Issue 10

Abstract

N-{[2-(Pyridin-4-ylcarbonyl)hydrazinyl]carbonothioyl}furan-2-carboxamide and its complexes with Ni(II), Co(II), Cu(II), Zn(II) and Mn(II) ions have been synthesized. The structure of the synthesized compounds was elucidated by elemental analysis, conductivity measurements, UV-visible, FT-IR, 1H NMR, powder XRD and thermal analysis studies. Most of metal complexes have exhibit thermal degradation between 80-750 °C and the powder X-rays diffraction data suggest that all the synthesized metal complexes were in nano crystalline phase. The computational molecular docking has been studied using Hex molecular modeling package version 8.2. The three dimensional structure of E. coli MurBenzyme (PDB code 2MBR) was used in microbial activity. The metal complexes showed comparable E total values with the standard drug tetracycline. The antioxidant and antimicrobial activity of prepared compounds indicate agreeable results versus bacterial strains three Gram-positive bacteria; S. aureus, S. pyogenes and P. acnes and three Gram-negative bacteria; E. coli, K. terrigena and K. pneumonia. The antifungal activity gave good results against fungal strains C. albicans, C. neoformans and Trichosporon.

Keywords

Thiosemicarbazone Transition metal(II) complexes Antioxidant Molecular docking
Yuvaraj, T., Naik, P. P., Krishnamurthy, G., Venkatesh, T., Shafeeulla, R. M., Manjuraj, T., & Venugopal, T. (2017). Synthesis, Characterization, Molecular Docking, Thermal Degradation Studies and Biological Screening of N-{[2-(Pyridin-4-ylcarbonyl)hydrazinyl]carbonothioyl}furan-2-carboxamide and its Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) Complexes. Asian Journal of Chemistry, 29(10), 2177–2183. https://doi.org/10.14233/ajchem.2017.20676
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