Preparation and in vitro Evaluation of Eudragit Microspheres Containing Cephalexin

Abstract

The aim of this study was to prepare and evaluate Eudragit microspheres containing cephalexin. Microspheres were prepared by emulsion solvent diffusion method. The prepared microspheres were analyzed for particle shape, particle size, percentage field, entrapment efficiency, stability studies and for in vitro release study. The size range of microspheres varies from 260.5-292.8 μm. Percentage yield and entrapment efficiency were found in the range of 72.8-79.6 % and 56.4- 66.8 % w/w, respectively. The in vitro release studies indicated that cephalexin loaded Eudragit microspheres provide sustained release over a period of 12 h.