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Synthesis of Thiadiazole and Azetidinone Derivatives Derived from Triazoles
Corresponding Author(s) : R. Yadav
Asian Journal of Chemistry,
Vol. 29 No. 10 (2017): Vol 29 Issue 10
Abstract
A series of novel thiadiazole and azetidinone derivatives of triazole nucleus were synthesized by the sequence of reactions with conventional and microwave techniques. The microwave technique is very useful with excellent yield at less reaction time compare to other conventional methods. The microwave synthesis of titled compound have been successfully performed in these conditions using environmentally friendly method with high atom economy. These compounds identified and characterized by physical and spectral (IR, NMR) techniques. All the synthesized compounds have been evaluated for their antibacterial and antifungal activity against bacteria Staphylococus aureus and Bacillus subtilis and fungi Fusarium oxisporum and Aspergillus niger when compared with standard drugs.
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- S.K. Srivastava, R. Yadav and S.D. Srivastava, J. Indian Chem. Soc., 81, 342 (2004).
- S. Guru, R. Yadav and S.K. Soumya Srivastava, J. Indian Chem. Soc., 83, 1236 (2006).
- C.G. Mortimer, G. Wells, J.-P. Crochard, E.L. Stone, T.D. Bradshaw, M.F.G. Stevens and A.D. Westwell, J. Med. Chem., 49, 179 (2006); https://doi.org/10.1021/jm050942k.
- R. Yadav, S.D. Srivastava and S.K. Srivastava, Proc. Natl. Acad. Sci. India, 75A, 165 (2005).
- J.V. Metzger, in eds.: A.R. Katritzsky and C.W. Rees, In Comprehensive Heterocyclic Chemistry, vol. 6, p. 322 (1984).
- P.C. Unangst, G.P. Shrum, D.T. Connor, R.D. Dyer and D.J. Schrier, J. Med. Chem., 35, 3691 (1992); https://doi.org/10.1021/jm00098a015.
- N.F. Eweiss and A.A. Bahajaj, J. Heterocycl. Chem., 24, 1173 (1987); https://doi.org/10.1002/jhet.5570240448.
- D. Li, D. Long and H. Fu, Synth. Commun., 35, 2495 (2005); https://doi.org/10.1080/00397910500212650.
- F. Broccolo, G. Cainelli, G. Caltabiano, C.E.A. Cocuzza, C.G. Fortuna, P. Galletti, D. Giacomini, G. Musumarra, R. Musumeci and A. Quintavalla, J. Med. Chem., 49, 2804 (2006); https://doi.org/10.1021/jm0580510.
- A. Jagmohan, P. Verma and K.V.S. Yamini, Indian J. Chem., 29, 88 (1990).
- M. Amir, M.S.Y. Khan and M.S. Iaman, Indian J. Chem., 43B, 2189 (2004).
- M.M. Kayser, M. Drolet and J.D. Stewart, Tetrahedron Asymm., 16, 4004 (2005); https://doi.org/10.1016/j.tetasy.2005.11.008.
- D.K. Shukla and S.D. Srivastava, Indian J. Chem., 47B, 463 (2008).
- Y.K. Agarwal and H.M. Joshira, Indian J. Chem., 44B, 1649 (2005).
- K.G. Desai and K.R. Desai, Indian J. Chem., 44B, 2093 (2005).
- J. Hartung, K. Daniel, T. Gottwald, A. Groß and N. Schneiders, Org. Biomol. Chem., 4, 2313 (2006); https://doi.org/10.1039/B603480B.
- R. Yadav, S.D. Srivastava and S.K. Srivastava, Indian J. Chem., 44B, 1262 (2005).
- S.K. Srivastava, R. Yadav and S.D. Srivastava, Indian J. Chem., 43B, 399 (2004).
References
S.K. Srivastava, R. Yadav and S.D. Srivastava, J. Indian Chem. Soc., 81, 342 (2004).
S. Guru, R. Yadav and S.K. Soumya Srivastava, J. Indian Chem. Soc., 83, 1236 (2006).
C.G. Mortimer, G. Wells, J.-P. Crochard, E.L. Stone, T.D. Bradshaw, M.F.G. Stevens and A.D. Westwell, J. Med. Chem., 49, 179 (2006); https://doi.org/10.1021/jm050942k.
R. Yadav, S.D. Srivastava and S.K. Srivastava, Proc. Natl. Acad. Sci. India, 75A, 165 (2005).
J.V. Metzger, in eds.: A.R. Katritzsky and C.W. Rees, In Comprehensive Heterocyclic Chemistry, vol. 6, p. 322 (1984).
P.C. Unangst, G.P. Shrum, D.T. Connor, R.D. Dyer and D.J. Schrier, J. Med. Chem., 35, 3691 (1992); https://doi.org/10.1021/jm00098a015.
N.F. Eweiss and A.A. Bahajaj, J. Heterocycl. Chem., 24, 1173 (1987); https://doi.org/10.1002/jhet.5570240448.
D. Li, D. Long and H. Fu, Synth. Commun., 35, 2495 (2005); https://doi.org/10.1080/00397910500212650.
F. Broccolo, G. Cainelli, G. Caltabiano, C.E.A. Cocuzza, C.G. Fortuna, P. Galletti, D. Giacomini, G. Musumarra, R. Musumeci and A. Quintavalla, J. Med. Chem., 49, 2804 (2006); https://doi.org/10.1021/jm0580510.
A. Jagmohan, P. Verma and K.V.S. Yamini, Indian J. Chem., 29, 88 (1990).
M. Amir, M.S.Y. Khan and M.S. Iaman, Indian J. Chem., 43B, 2189 (2004).
M.M. Kayser, M. Drolet and J.D. Stewart, Tetrahedron Asymm., 16, 4004 (2005); https://doi.org/10.1016/j.tetasy.2005.11.008.
D.K. Shukla and S.D. Srivastava, Indian J. Chem., 47B, 463 (2008).
Y.K. Agarwal and H.M. Joshira, Indian J. Chem., 44B, 1649 (2005).
K.G. Desai and K.R. Desai, Indian J. Chem., 44B, 2093 (2005).
J. Hartung, K. Daniel, T. Gottwald, A. Groß and N. Schneiders, Org. Biomol. Chem., 4, 2313 (2006); https://doi.org/10.1039/B603480B.
R. Yadav, S.D. Srivastava and S.K. Srivastava, Indian J. Chem., 44B, 1262 (2005).
S.K. Srivastava, R. Yadav and S.D. Srivastava, Indian J. Chem., 43B, 399 (2004).