Microwave Assisted Synthesis, Characterization and Pharmacological Evaluation of Pyridazinone Derivatives

Abstract

Two series of compounds (i) 2-substituted phenyl-10H-pyridazin (6,1-b)quinazoline-10-one (4a-g) and (ii) 6-substituted phenyl tetrazolo (1,5-b)pyridazine (5a-g) were synthesized by microwave assisted methods. These compounds were evaluated for their hypotensive and anticonvulsant activities. These drugs showed the hypotensive activity ranging from 17.8 to 27.4 % while standard drug minoxidil showed 27 % reduction in blood pressure. All these compounds showed significant anticonvulsant activity when compared with phenytoin.