Microwave Mediated Synthesis and Antimicrobial Screening of 2,6-Diaryl-3-methyl-4-piperidyl carbazone Derivatives

Abstract

Microwave irradiation technique as a green chemistry procedure have been applied to the synthesis of a series of some new 2,6-diaryl-3- methyl-4-piperidyl carbazone derivatives (2a-f) which was obtained by the reaction of 2,6-diaryl-3-methyl-4-piperidone (1a-c) with semicarbazide or thiosemicarbazide respectively. The key intermediate 1a-c were prepared in one step by reacting ethyl methyl ketone, various substituted aldehydes and ammonium acetate. The chemical structures of the synthesized compounds were confirmed by IR, ¹H NMR and mass spectral data. The compounds were screened for antibacterial and antifungal activity. Majority of the compounds showed significant antimicrobial activity.