Synthesis of Bioactive Isothiazoline Derivatives

Abstract

In present, some nitrogen and sulfur containing heterocycles are synthesized. The compounds 3-(2'-hydroxy-3'-iodo-4'-ethoxy-5-bromo phen-l'-yl)-5-substituted-2- isoxazoline have been synthesized by the condensation of 2'-hydroxy-3'-iodo-4'-ethoxy-5-bromo substituted chalcone with hydroxylamine hydrochloride to produce isoxazoline, which again treated with P₂S₅ in presence of pyridine to give 3-(2'-hydroxy- 3'-iodo-4'-ethoxy-5'-bromo phen-l'-yl)-5-substituted-2- isothiazoline. All the compounds have been characterized by elemental analysis IR, NMR and Mass spectral data. All the compounds have been screened for their antimicrobial activity to gram positive and gram negative bacterial strains and antifungal activity.