Simultaneous Estimation of Residual Solvents (Ethanol, Acetone, Dichloromethane and Ethyl Acetate) in Dosage Form by GC-HS-FID
Corresponding Author(s) : Praveen Kumar Baliyan
praveenbaliyanraj@yahoo.co.in
Asian Journal of Chemistry,
Vol. 21 No. 8 (2009): Vol 21 Issue 8
Abstract
A simple and sensitive method for the determination of ethanol, acetone, dichloromethane and ethyl acetate as residual solvent was developed and validated on gas liquid chromatography with headspace sampler fitted with flame ionization detector (GC-HS-FID). The carrier gas was helium and separation was carried out on Elite-624 (30 meter, 0.53 mm ID, 3μm df) capillary column consisting of 6 % cyanopropylphenyl- 94 % dimethyl polysiloxane stationary phase. The retention time for ethanol, acetone, dichloromethane and ethyl acetate were 11.4, 12.7, 14.0 and 16.9 min, respectively.
Keywords
Acetone
Dichloromethane
Ethyl acetate
GC-HS-FID
Ethanol
(1)
Kumar Baliyan, P.; Singh, R.; Arora, S. Simultaneous Estimation of Residual Solvents (Ethanol, Acetone, Dichloromethane and Ethyl Acetate) in Dosage Form by GC-HS-FID. ajc 2010, 21, 5851-5857.
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