Spectrophotometric Determination of Ziparsidone Hydrochloride Using N-Bromosuccinimide and Metol

Abstract

Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of ziparsidone hydrochloride (ZPD) based on the formation of oxidation and precipitation products. Method A involves the oxidation of the ZPD with N-bromo succinimide (NBS) and estimation of the unconsumed NBS with p-N-methyl aminophenol-sulphanilamide (PMAP-SA) reagent. Method B includes the estimation of unreacted NBS using a known excess celestine blue and the dye remaining was then measured. Quantitative precipitation of drug with tannic acid under acidic conditions and estimating the unreacted tannic acid in the filtrate with PMAP-Cr(VI) is proposed in method C.