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Vol. 29 No. 10 (2017): Vol 29 Issue 10

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Click Synthesis of Some mono/bis 1,2,3-Triazoles with Ester Linkage and their Microbicidal Activity

https://doi.org/10.14233/ajchem.2017.20671
C.P. Kaushik
Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar-125 001, India
Ashima Pahwa
Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar-125 001, India

Corresponding Author(s) : C.P. Kaushik

kaushikcp@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 10 (2017): Vol 29 Issue 10

Abstract

Synthesis of some new 1,4-disubstituted 1,2,3-triazoles with ester functionality is reported employing Cu(I) catalyzed Huisgen [3+2] cycloaddition reaction of prop-2-yn-1-yl benzoates with 1,4-phenylenebis(methylene) bis(2-azidoacetate) and benzyl 2-azidoacetates. The synthesized compounds were well characterized through FTIR, 1H NMR, 13C NMR and HRMS. Further, the synthesized triazole derivatives were accessed for in vitro antimicrobial activity against one Gram-positive bacterial strain Staphylococcus aureus, three Gram-negative bacterial strains Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and two fungi Candida albicans and Aspergillus niger. Few of the synthesized disubstituted 1,2,3-triazoles displayed moderate to good inhibitory activity against tested microbial strains.

Keywords

Click synthesis Huisgen [3 2] dipolar cycloaddition Disubstituted 1,2,3-triazoles Antibacterial activity Antifungal activity
Kaushik, C., & Pahwa, A. (2017). Click Synthesis of Some mono/bis 1,2,3-Triazoles with Ester Linkage and their Microbicidal Activity. Asian Journal of Chemistry, 29(10), 2171–2176. https://doi.org/10.14233/ajchem.2017.20671
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