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Vol. 29 No. 10 (2017): Vol 29 Issue 10

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Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand, India

https://doi.org/10.14233/ajchem.2017.20622
Jyotsna Dhanik
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar-263 145, India
Ankita Verma
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar-263 145, India
Neelam Arya
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar-263 145, India
Om Prakash
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar-263 145, India
Vivekanand
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar-263 145, India

Corresponding Author(s) : Vivekanand

imvivekanand@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 10 (2017): Vol 29 Issue 10

Abstract

In recent years, a great significant attention has been drawn to natural compounds rather than synthetic compounds due to their less side effects or without side effects in therapeutic. Present work deals with chemical composition and in vitro antibacterial activity of methanolic extracts of five ginger accessions collected from different places of Uttarakhand, India. Molecular docking is performed between phytocompounds identified through GC-MS analysis and bacterial protein PDB ID: 1QFE and PDB ID: 2VF5. By comparing the scoring results of compositions in extracts of ginger rhizomes with bacterial protein, we can infer the antibacterial activity about selected phytocompounds. Molecular-docking analysis and antimicrobial test proved that methanolic extract of ginger accession from Dharchula had strong antibacterial effects.

Keywords

Ginger Antibacterial Molecular docking Zingerone Gingerol
Dhanik, J., Verma, A., Arya, N., Prakash, O., & Vivekanand, . (2017). Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand, India. Asian Journal of Chemistry, 29(10), 2123–2128. https://doi.org/10.14233/ajchem.2017.20622
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References
  1. F.A. Jones, Eur. J. Gastroenterol. Hepatol., 8, 1227 (1996); https://doi.org/10.1097/00042737-199612000-00018.
  2. M.L. Balchin and S.G. Deans, J. Appl. Bacteriol., 82, 759 (1997); https://doi.org/10.1046/j.1365-2672.1997.00153.x.
  3. S.R. Uhl, Handbook of Spices, Seasonings and Flavorings, Technomic Pub, Lancaster, PA, USA, edn 1 (2000).
  4. V.S. Govindarajan and D.W. Connell, Crit. Rev. Food Sci. Nutr., 17, 1 (1983); https://doi.org/10.1080/10408398209527343.
  5. P.N. Ravindran and B.K. Nirmal Ginger, The Genus Zingiber, Medicinal and Aromatic Plant-Industrial Profile, CRC Press, Florida, USA (2005).
  6. R.P. Adams, Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, Allured publishing Corporation, Carol Stream Illlinois, USA (2007).
  7. G. Singh, P. Marimuthu, H.S. Murali and A.S. Bawa, J. Food Saf., 25, 130 (2005); https://doi.org/10.1111/j.1745-4565.2005.00564.x.
  8. A.W. Bauer, W.M. Kirby, J.C. Sherris and M. Turck, Am. J. Clin. Pathol., 45, 493 (1966).
  9. NCCLS, PErformance Standards for Antimicrobial Disk Susceptibility Tests: Approval Standard M2-A7, Clinical and Laboratory Standards Institute, Pennsylvania, edn 7 (2000).
  10. R. Thomsen and M.H. Christensen, J. Med. Chem., 49, 3315 (2006); https://doi.org/10.1021/jm051197e.
  11. C. Ramathilagam, A. Upgade, A. Bhaskar, P.R. Umarani and V. Manivannan, Asian J. Pharm. Clin. Res., 6, 96 (2013).
  12. N.C. Azu and R.A. Onyeagba, Int. J. Trop. Med., 3, 1 (2007).
  13. P. Kaushik and P. Goyal, Adv. Microbiol., 1, 7 (2011); https://doi.org/10.4236/aim.2011.11002.
  14. U.N. Ekwenye and N.N. Elegalam, J. Mol. Med. Adv. Sci., 1, 411 (2005).
  15. R.D. Hiserodt, S.G. Franzblau and R.T. Rosen, J. Agric. Food Chem., 46, 2504 (1998); https://doi.org/10.1021/jf970948l.
  16. S. Krist, D. Banovac, N. Tabanca, D.E. Wedge, V.K. Gochev, J. Wanner, E. Schmidt and L. Jirovetz, Nat. Prod. Commun., 10, 143 (2015).
  17. L. Kumar, S. Chhibber and K. Harjai, Fitoterapia, 90, 73 (2013); https://doi.org/10.1016/j.fitote.2013.06.017.
  18. H.J. Lee, Y.R. Ji, Z.Y. Ryoo, M.S. Choi, E.R. Woo and D.G. Lee, Curr. Microbiol., 72, 48 (2016); https://doi.org/10.1007/s00284-015-0918-3.
  19. C. Nagoshi, S. Shiota, T. Kuroda, T. Hatano, T. Yoshida, R. Kariyama and T. Tsuchiya, Biol. Pharm. Bull., 29, 443 (2006); https://doi.org/10.1248/bpb.29.443.
  20. M. Park, J. Bae and D.-S. Lee, Phytother. Res., 22, 1446 (2008); https://doi.org/10.1002/ptr.2473.
  21. G.N. Santos da Silva, P. Pozzatti, F. Rigatti, R. Hörner, S. Hartz Alves, C.A. Mallmann and B.M. Heinzmann, J. Microbiol. Biotechnol. Food Sci., 4, 434 (2015); https://doi.org/10.15414/jmbfs.2015.4.5.434-436.
  22. V.K. Bajpai, S.M. Al-Reza, U.K. Choi, J.H. Lee and S.C. Kang, Food Chem. Toxicol., 47, 1876 (2009); https://doi.org/10.1016/j.fct.2009.04.043.
  23. M.H.J. Ultee, M.H.J. Bennik and R. Moezelaar, Appl. Environ. Microbiol., 68, 1561 (2002); https://doi.org/10.1128/AEM.68.4.1561-1568.2002.
  24. M. Tajkarimi, S. Ibrahim and D. Cliver, Food Control, 21, 1199 (2010); https://doi.org/10.1016/j.foodcont.2010.02.003
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