Synthesis, Characterization and Biological Activity of Some Thiophene Substituted Biheterocycles Containing Oxadiazoles

Abstract

5-(2-Amino-4,5,6,7- tetrahydro-1-benzothien-3-yl) N-substituted 1,3,4-oxadiazole-2-amines (IVa-e) were synthesized by treating (IIIa-e) with NaOH. Compounds (IIIa-e) were synthesized by treating 2-amino- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbohydrazide (II) with isothiocyanate. Compound II was synthesized by treating ethyl 2-amino- 4,5,6,7-tetra hydrobenzeno[b]thiophene-3-carboxylate (I) with hydrazine hydrate. Compound I was prepared by treating cyclohexanone, sulphur, ethylcyanoacetate with diethyl amine. All the synthesized compounds were charecterized by IR, NMR and mass spectrometry and then evaluated for antiinflammatory and antibacterial activity againt Staphylococcus aureus, Escherichia coli, Bacillus pumilis, Bacillus subtilis and Pseudomonas aerugenosa.