Adamantane-Containing Biological Active Compounds: Synthesis, Properties and Use

Abstract

New biological active adamantane-containing anilides and nitro anilides have been synthesized and studied. The quantum-chemical investigation of these compounds has been carried out. By the semiempirical method AM1 effective charges on the atoms, bonds lengths and valence angles, enthalpies of formation of initial compounds and probable obtained products of the reaction of nitration of the anilides have been calculated. Based on quantum-chemical calculations and experimental data the direction of the reaction of nitration has been established. The anthelmintic activity and activity towards various microorganisms of the obtained compounds have been studied. The obtained compounds may be recommended as modifier of anthelmintic preparation - phenacetyne, trinoine, diamphenetide, raphoxanide also as a bioactive component for preparation: a) materials with antimycotic properties for prophylaxis and treatment of mycosis and dermatomycosis: adhesive compositions in the form polymer systems; b) protective covers stable to biocorrosion from action some micopathogenic microorganisms.