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Vol. 21 No. 9 (2009): Vol 21 Issue 9

In Silico Screening of Pyridine Derivatives as Potential DHFR Inhibitors for Anticancer Activity

A.G. NERKAR
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India
S.A. GHONE
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India
A. SAREEN
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India
A. MEHTA
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India
S.A. BHAGAT
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India
K.P. MOHANRAJ
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India
A.K. THAKER
Department of Pharmaceutical and Medicinal Chemistry, School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai-400 056, India

Corresponding Author(s) : A.G. NERKAR

agn971981@yahoo.co.in

Asian Journal of Chemistry, Vol. 21 No. 9 (2009): Vol 21 Issue 9

Abstract

In this paper, in silico screening prioritization of some pyridinyl Schiff bases (Schiff bases of isoniazid (INH)) as inhibitors of mammalian dihydrofolate reductase enzyme (DHFR) for anticancer activity, before actual synthesis of the molecules and anticancer evaluation are reported.

Keywords

In silico screening Isoniazid Schiff's bases DHFR ADME Docking
NERKAR, A., GHONE, S., SAREEN, A., MEHTA, A., BHAGAT, S., MOHANRAJ, K., & THAKER, A. (2010). In Silico Screening of Pyridine Derivatives as Potential DHFR Inhibitors for Anticancer Activity. Asian Journal of Chemistry, 21(9), 6975–6980. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/12173
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