Synthesis and Biological Evaluation of Some Novel Chalcone Derivatives

Abstract

In this study, substituted chalcone derivatives were synthesized and their analgesic and antiinflammatory activities were assayed. Chalcone derivatives were prepared by the treatment of substituted acetophenone with substituted aromatic and hetero aromatic aldehydes. The structure elucidation of the compounds was performed by UV, IR, ¹H NMR. Generally the prepared compound exhibited only moderate analgesic and antiinflammatory activities in mice at the dose of 100 mg/kg i.p.; however, a few of them exhibited good activity, almost equivalent to that of aspirin at 1 mg/kg was observed. At the above dosage, no toxicity was observed for all compounds.