Synthesis and Characterization of Glycerol Dimethacrylate-4-vinyl pyrrole

Abstract

The successful application of 10 % glycerol dimethacrylate (GDMA) crosslinked 4-vinyl pyrrole (4-VP) support in manual solid phase organic reactions are reported. The copolymer was prepared using benzoyl peroxide as initiator via suspension polymerization in polyvinyl alcohol yielding a beaded resin. GDMA-4VP resin undergoes facile swelling in a variety of solvents both polar and non-polar used in peptide synthesis. The resin was chloromethylated using chloromethyl methyl ether and the chlorine capacity was determined by pyridine fusion method. The chloromethyl resin converted to aminomethyl resin by inter group conversion.