New Antifungal Constituent from the Tricholepsis glaberrima DC

Abstract

A new flavone glycoside 1 m.p. 242-244 °C, m.f. C₃₅H₄₄O₂₀, [M]⁺ 784 (FABMS), has been isolated from the methanolic extract of the flowers of the plant Tricholepsis glaberrima DC. alongwith a known compound 1a, 7,3'-dihydroxy-6,4'-dimethoxy flavone. Compound 1 was characterized as a new flavone glycoside, 5,2'-dihydroxy-3,6,7- trimethoxy flavone-5-O-α-L-rhamnopyranosyl-(1→4)-O-β-Dxylopyranosyl-( 1→4)-O-β-D-galactopyranoside by several colour reactions, spectral analysis and chemical degradations. Compound 1 showed antifungal activity against various fungi.