Synthesis of Quinazoline Derivatives and their Biological Activities

Abstract

A series of novel 4-oxo-2-phenyl-4H-quinazoline-3-carboxylic acid (4-substituted phenyl amides) have been synthesized by condensing 2-phenyl-3,1-benzoxazine-4-one and 4-substiuted phenyl ureas. A mixture of N-benzoyl anthranilic acid and acetic anhydride was condensed to form 2-phenyl-3,1-benzoxazine-4-one and various 4-substituted anilines were condensed with sodium cyanide to form 4-substituted phenyl ureas. The structures of the synthesized compounds were also elucidated. The synthesized compounds were found to have significant effect against the tested microorganisms.