Anticonvulsant and Neurotoxicity Evaluation of Some Novel 2-(1H-Benzotriazol-1-yl)-N'-[substituted] acetohydrazide

Abstract

A series of novel 2-(1H-benzotriazol-1-yl)-N'-[substituted] acetohydrazide were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and subcutaneous metrazol (scMET) induced seizure models in mice. The neurotoxicity was assessed using the Rotorod method. The compound N'-[4-(1,3-benzodioxol-5-yloxy)benzylidene]-2-(1Hbenzotriazol- 1-yl)aceto-hydrazide (BTA 9) emerged as the most promising one with anti-MES activity in mice i.p. All the compounds exhibited no neurotoxicity in Rotorod method.