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Vol. 22 No. 10 (2010): Vol 22 Issue 10

Synthesis and DNA Binding Studies of a Tetraazamacrocyclotetradecane Co(II) Complex

Jian-Hong Bi
Deparment of Chemistry and Chemical Engineering, Hefei Normal University, Hefei, P.R. China
Yuan-Ying Cao
Anhui Medical College, Hefei 230061, PR China ; Deparment of Chemistry and Chemical Engineering, Hefei Normal University, Hefei, P.R. China
Man Cui
Shuangdun Middle School, Changfeng County, Hefei 231131, P.R. China

Corresponding Author(s) : Yuan-Ying Cao

bi010101@126.com

Asian Journal of Chemistry, Vol. 22 No. 10 (2010): Vol 22 Issue 10

Abstract

A tetraazamacrocyclotetradecane cobalt(II) complex, CoL·(ClO4)2 (L = 5,5,7,12,12,14- hexamethyl-1,4,8,11-tetraazamacrocyclotetradecane) was synthesized and characterized by IR spectra and elemental analysis. The interaction of the CoL·(ClO4)2 with DNA were studied by cyclic voltammetry. In the presence of DNA, the reduction peak of CoL·(ClO4)2 shifted to more positive values and the peak current decreased significantly. The experimental results indicate that the complex could interact with DNA by intercalation binding.

Keywords

Tetraazamacrocycle Cobalt(II) complex Synthesis DNA Cyclic voltammetry Intercalation
Bi, J.-H., Cao, Y.-Y., & Cui, M. (2010). Synthesis and DNA Binding Studies of a Tetraazamacrocyclotetradecane Co(II) Complex. Asian Journal of Chemistry, 22(10), 8143–8146. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/12116
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