Synthesis and Antimicrobial Activity of Novel Formazans and Their Tetrazolium Bromides

Abstract

Novel formazans [III(a-l)] have been synthesized by the coupling reaction of diazotized solution of substituted sulfanilamide derivatives with aryl hydrazones of different benzaldehydes in pyridine. The resultant formazans were further cyclized by H₂SO₄,H₂O₂/Fe²⁺, NaBr to prepare the corresponding tetrazolium bromides [IV(a-l)]. The compounds were characterized by ¹H NMR, IR and elemental analysis. The compounds were assayed for antimicrobial activity.