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Vol. 22 No. 10 (2010): Vol 22 Issue 10

Quantitative Determination of Anticancer Drug Heptaplatin by HPLC

Xuefeng He
School of Chemistry and Chemical Engineering, Yunnan Normal University, 650092, P.R. China
Ping Zhen
School of Chemistry and Chemical Engineering, Yunnan Normal University, 650092, P.R. China
Xizhu Chen
State Key Laboratory of Advanced Technologies for Platinum Group Metals, Kunming Institute of Precious Metals, 650106, P.R. China
Shuiyan Yang
School of Chemistry and Chemical Engineering, Yunnan Normal University, 650092, P.R. China
Xiaotian Xie
School of Chemistry and Chemical Engineering, Yunnan Normal University, 650092, P.R. China
Weiping Liu
State Key Laboratory of Advanced Technologies for Platinum Group Metals, Kunming Institute of Precious Metals, 650106, P.R. China

Corresponding Author(s) : Weiping Liu

liuweiping0917@126.com; xt6207@yahoo.com.cn

Asian Journal of Chemistry, Vol. 22 No. 10 (2010): Vol 22 Issue 10

Abstract

A method for the direct determination of anticancer drug heptaplatin by HPLC has been described. Phenomenex ODS column (150 mm × 4.6 mm i.d., 5 μm) was used as the stationary phase and a mixture of methanol and water (40:60, v/v) as the mobile phase. The flow rate was 1.0 mL min-1, T = 40 ºC and the detection wavelength was 230 nm. Under these analytical conditions, the linear regression coefficient was found to be 0.9999, the average recovery exceeded 99.9 % with RSD 0.85 %. The method is accurate, reliable and rapid. It can be applied to the quality control of heptaplatin.

Keywords

HPLC Anticancer drug Heptaplatin Analysis
(1)
He, X.; Zhen, P.; Chen, X.; Yang, S.; Xie, X.; Liu, W. Quantitative Determination of Anticancer Drug Heptaplatin by HPLC. ajc 2010, 22, 8174-8178.
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