Anticancer Activity of Thiazole-Incorporated Synthetic Wainunuamide

Abstract

A cyclic heptapeptide wainunuamide isolated from Fijian marine sponge was synthesized by using solution phase peptide synthesis technique. The synthesized wainunuamide compound had shown moderate activity towards HeLa Cancer cell lines. To increase the anticancer activity of the synthesized compound a thiazole moiety is incorporated in the wainunuamide compound. The synthesized compounds were charac-terized by FTIR, ¹H NMR and mass spectral analysis. The thiazole incor-porated synthetic wainunuamide was tested for its anticancer activity (cell line-MCF7 cells). The compound exhibited potent anticancer activity.