Copyright (c) 2017 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Characterization of Antitubercular Triazine-Chalcone Hybrid Molecules
Corresponding Author(s) : Harpreet Kaur
Asian Journal of Chemistry,
Vol. 29 No. 9 (2017): Vol 29 Issue 9
Abstract
A new series of 1,3,5-triazine-chalcone hybrid molecules have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. The antitubercular activity screening data revealed that the compounds 1 and 2B demonstrated comparatively the most potent inhibitory activity, with MIC value 1.6 μg/mL. Most of the compounds displayed significantly promising activity.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- V.R. Avupati and R.P. Yejella, World J. Pharm Pharm. Sci., 3, 278 (2014).
- R. Ghosh and A. Das, World J. Pharm. Pharm. Sci., 3, 578 (2014).
- A. Solanki and R. Patel, Indian J. Chem., 53B, 1448 (2014).
- M.R. Gajula and Y.V.R. Reddy, Eur. J. Chem., 5, 374 (2014); https://doi.org/10.5155/eurjchem.5.2.374-379.1027.
- S.R. Dwarampudi, G.S. Dannana, V.R. Avupati and V.S.M. Bendi, Eur. J. Chem., 5, 570 (2014); https://doi.org/10.5155/eurjchem.5.4.570-576.1098.
- R. Saha, M.M. Alam and M. Akhter, RSC Adv., 5, 12807 (2015); https://doi.org/10.1039/C4RA14440F.
- V. Sharma and K.V. Sharma, Rasayan J. Chem., 4, 17 (2011).
- F.G. Khan, M.V. Yadav, S.R. Khapate and A.D. Sagar, Indo-Am. J. Pharm. Res., 5, 1447 (2015).
- S. Syam, S.I. Abdelwahab, M.A. Al-Mamary and S. Mohan, Molecules, 17, 6179 (2012); https://doi.org/10.3390/molecules17066179.
- A. Solankee, K. Patel and R. Patel, E-J. Chem., 9, 1897 (2012); https://doi.org/10.1155/2012/638452.
- A. Solankee and Y. Prajapati, Rasayan J. Chem., 2, 9 (2009).
- M.C.S. Lourenço, M.V.N. de Souza, A.C. Pinheiro, M. de L. Ferreira, R.S.B. Gonçalves, T.C.M. Nogueira and M.A. Peralta, Arkivoc, 181 (2007); https://doi.org/10.3998/ark.5550190.0008.f18.
References
V.R. Avupati and R.P. Yejella, World J. Pharm Pharm. Sci., 3, 278 (2014).
R. Ghosh and A. Das, World J. Pharm. Pharm. Sci., 3, 578 (2014).
A. Solanki and R. Patel, Indian J. Chem., 53B, 1448 (2014).
M.R. Gajula and Y.V.R. Reddy, Eur. J. Chem., 5, 374 (2014); https://doi.org/10.5155/eurjchem.5.2.374-379.1027.
S.R. Dwarampudi, G.S. Dannana, V.R. Avupati and V.S.M. Bendi, Eur. J. Chem., 5, 570 (2014); https://doi.org/10.5155/eurjchem.5.4.570-576.1098.
R. Saha, M.M. Alam and M. Akhter, RSC Adv., 5, 12807 (2015); https://doi.org/10.1039/C4RA14440F.
V. Sharma and K.V. Sharma, Rasayan J. Chem., 4, 17 (2011).
F.G. Khan, M.V. Yadav, S.R. Khapate and A.D. Sagar, Indo-Am. J. Pharm. Res., 5, 1447 (2015).
S. Syam, S.I. Abdelwahab, M.A. Al-Mamary and S. Mohan, Molecules, 17, 6179 (2012); https://doi.org/10.3390/molecules17066179.
A. Solankee, K. Patel and R. Patel, E-J. Chem., 9, 1897 (2012); https://doi.org/10.1155/2012/638452.
A. Solankee and Y. Prajapati, Rasayan J. Chem., 2, 9 (2009).
M.C.S. Lourenço, M.V.N. de Souza, A.C. Pinheiro, M. de L. Ferreira, R.S.B. Gonçalves, T.C.M. Nogueira and M.A. Peralta, Arkivoc, 181 (2007); https://doi.org/10.3998/ark.5550190.0008.f18.