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Vol. 22 No. 10 (2010): Vol 22 Issue 10

Synthesis and Characterization of Some Mannich Bases as Potential Antimicrobial Agents

Hemendra S. Chouhan
School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyala, Bhopal-462 036, India ; Pharmaceutical Chemistry Research Lab., Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221 005, India.
Sushil K. Singh
Pharmaceutical Chemistry Research Lab., Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221 005, India.
N.S.H.N. Moorthy
School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyala, Bhopal-462 036, India

Corresponding Author(s) : Hemendra S. Chouhan

hschouhan.rs.phe@itbhu.ac.in

Asian Journal of Chemistry, Vol. 22 No. 10 (2010): Vol 22 Issue 10

Abstract

A series of Mannich base derived from the substituted acetophenone were synthesized under the acidic condition and evaluated for the antimicrobial activity by the disc diffusion method. Chemical structures of synthesized Mannich base were determined by FTIR, 1H NMR, FABMS spectroscopic analysis. The results showed that the Mannich bases were successfully synthesized under the acidic condition and compound 4 in the series possess the significant antimicrobial activity.

Keywords

Mannich base Antibacterial activity Antifungal activity
S. Chouhan, H., K. Singh, S., & Moorthy, N. (2010). Synthesis and Characterization of Some Mannich Bases as Potential Antimicrobial Agents. Asian Journal of Chemistry, 22(10), 7903–7908. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/12079
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