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Vol. 22 No. 10 (2010): Vol 22 Issue 10

Antileukemic Activity and Chemical Constituents of Some Zingiberaceae Species

M.A. Sukari
Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, UPM, Selangor Darul Ehsan, Malaysia
S.W. Tang
Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, UPM, Selangor Darul Ehsan, Malaysia
B.K. Neoh
Sime Darby Technology Centre, 2, Jalan Tandang, 46050 Petaling Jaya, Selangor, Malaysia.
G.C.L. Ee
Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, UPM, Selangor Darul Ehsan, Malaysia
M. Rahmani
Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, UPM, Selangor Darul Ehsan, Malaysia

Corresponding Author(s) : M.A. Sukari

aspollah@fsas.upm.edu.my; swjune@hotmail.com

Asian Journal of Chemistry, Vol. 22 No. 10 (2010): Vol 22 Issue 10

Abstract

Crude extracts of various solvents from six species (genus Alpinia, Zingiber, Kaempferia) of Zingiberaceae family have been chosen for the in vitro cytotoxic activity screening against the inhibition of HL-60 cell line (Human promyelocytic leukemia). Eight extracts (44 %) were found to have cytotoxic activity with IC50 values less than 30 μg/mL, with Alpinia galanga showing the most prominent antileukemic activity. Further isolation work on Kaempferia galanga has yielded ethyl p-methoxy-trans-cinnamate (1), p-methoxy-trans-cinnamic acid (2) besides b-sitosterol.

Keywords

Zingiberaceae Antileukemic Alpinia Zingiber Kaempferia
(1)
Sukari, M.; Tang, S.; Neoh, B.; Ee, G.; Rahmani, M. Antileukemic Activity and Chemical Constituents of Some Zingiberaceae Species. ajc 2010, 22, 7891-7896.
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