Determination of Metformin Hydrochloride in Pharmaceutical Formulations

Abstract

Metformin hydrochloride is an antidiabetic drug of biguanide category with multiple benefits in type II diabetes mellitus e.g., lowering of HbA_1c values, lipid profile regulation and improvement in vascular and hemodynamic indices. Adverse effects are generally tolerable and self-limiting. Alone as well as in combination with other antidiabetic drugs of different categories, it is administered in different formulations. Due to short biological half-life (2-6 h), it is available in sustained release formulations. The present study concentrates on the various analytical methods of metfromin hydrochloride determination in dosage forms as well in blood plasma.