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Vol. 22 No. 10 (2010): Vol 22 Issue 10

Synthesis and Calf-thymnus DNA Interaction Studies of Ni(II)L Complex

Jian-Hong Bi
Deparment of Chemistry and Chemical Engineering, Hefei Normal University, Hefei, P.R. China
Wen-Bo Tao
Pharmaron Beijing Limited Co., No.18, South Xihuan Road, BDA, Beijing, 100176, P.R. China
Lin Wang
Deparment of Chemistry and Chemical Engineering, Hefei Normal University, Hefei, P.R. China

Corresponding Author(s) : Jian-Hong Bi

bi010101@126.com

Asian Journal of Chemistry, Vol. 22 No. 10 (2010): Vol 22 Issue 10

Abstract

The tetraza macrocyclic nickel(II)L complex, L = 5,5,7,12,12,14-hexamethyl-1,4,8,11- tetraazamacrocyclic-4,11-diene(ClO4)2, was synthesized by hydrothermal method and characterized by IR spectra and elemental analysis. The interaction of nickel(II)L with calf thymus DNA was studied using UV-vis spectrum, fluorescence-based assays and viscometry. All experimental results indicated that the complex interacted with DNA by the main mode of interaction between nickel(II)L and DNA is a partial intercalation mode.

Keywords

Tetraza macrocycle Nickel(II) complex Synthesis DNA Intercalation
(1)
Bi, J.-H.; Tao, W.-B.; Wang, L. Synthesis and Calf-Thymnus DNA Interaction Studies of Ni(II)L Complex. ajc 2010, 22, 8270-8272.
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